The vitamin D receptor (VDR) is a proteins that is stimulated by calciferol. It is interested in maintaining the mineral balance in the body and comparison of data room software causing growth and hair expansion. It also interacts with adipose muscle.

VDRs happen to be expressed inside the parathyroid glands, intestines, epithelial cellular material, and many immune cell types. They are believed to regulate the intestinal absorption of calcium supplement, and to mediate some of the effects of vitamin D on bone protection. Also, they are thought to play an important function in metabolism.

VDR can be found in a variety of tissues, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they can be most widely portrayed in the kidneys and osseous matter.

The VDR is phosphorylated in serine residues by several protein kinases. These kinases include PKA and PKC. The effect for these kinases upon VDR can be ligand based mostly. Specifically, the phosphorylation of Ser51 by simply PKC reduced VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.

Research have shown that VDRs are present in a subsection, subdivision, subgroup, subcategory, subclass of glial cells, particularly in oligodendrocytes in white matter. Although VDR immunoreactivity has been discovered in a number of glial cell lines, no research has been offered that the occurrence of VDR in glia is a cause for increased risk of tumorigenesis.

Additionally , VDR seems to be present in a subset of neurons. Actually nuclear staining has been has confirmed in human being cortex and glial cell-lines.

A large 220-kDa protein can be found in human principal glioblastoma cellular material. In contrast, a little recombinant VDR-like protein was produced.